Two sample MR report
HLA-DRB5_Endothelial Cell (Endo) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 20 | -0.0124600 | 0.0251558 | 0.6263727 |
| Weighted median | 20 | -0.0192788 | 0.0064609 | 0.0028459 |
| Inverse variance weighted | 20 | -0.0196132 | 0.0049360 | 0.0000708 |
| Simple mode | 20 | -0.0186620 | 0.0099918 | 0.0773040 |
| Weighted mode | 20 | -0.0176025 | 0.0091513 | 0.0695329 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.821345 | 18 | 0.9968686 |
| Inverse variance weighted | 5.905441 | 19 | 0.9981432 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0055994 | 0.0193086 | 0.7751357 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003904 | 0 | TRUE | 0.0608853 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
